10:15, 16 April 2025 by admin | Paper

Hamzah, Suryanti Suryanti, Idris Adewale Ahmed, Bambang Pudjo Semedi, Abdullah Machin, Aditya Tri Hernowo

Abstract

Stroke remains a leading cause of mortality and long-term disability worldwide, necessitating innovative therapeutic strategies. The advent of nanotechnology, particularly oxygen-delivering nanobubbles (ODNBs), has introduced a promising avenue for enhancing stroke therapy. ODNBs have demonstrated the ability to improve oxygen delivery, enhance therapeutic efficacy, and provide diagnostic advantages through imaging contrast enhancement. However, challenges such as toxicity, off-target effects, and regulatory hurdles must be addressed before clinical translation. This review synthesizes the latest findings on ODNBs in stroke therapy, highlights their key benefits and challenges, and explores future applications, including gene therapy and brain tissue regeneration. By addressing these aspects, this review aims to provide a comprehensive understanding of the potential of ODNBs in revolutionizing stroke treatment.

Keywords: nanobubles, oxygen, role, stroke, ischemic

Article Link: https://f1000research.com/articles/14-406

Share: